Season 5 of Grey’s Anatomy is currently available in United States across 6 streaming offer(s).

Grey’s Anatomy – Season 5 (2008)

84%

TMDB8.4

24 episodes

43m

Grey’s Anatomy - Season 5 Plot SummaryGrey’s Anatomy - Season 5 was released on September 25, 2008. Live for the moment. Dive deeper into the lives and loves of "Grey's Anatomy"! The doctors struggle...

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Grey’s Anatomy – Season 5 Plot Summary

Grey’s Anatomy – Season 5 was released on September 25, 2008. Live for the moment. Dive deeper into the lives and loves of "Grey's Anatomy"! The doctors struggle and thrive as they enter uncharted territories of life. Discover what happens in the on-again, off-again world of Derek and Meredith, and witness the budding relationship between Cristina and Owen, Seattle Grace's newest doctor.

Grey’s Anatomy – Season 5 Cast, Characters, and Arc

Confirmed cast for Grey’s Anatomy – Season 5 includes Ellen Pompeo, Chandra Wilson, Sandra Oh, Justin Chambers, and James Pickens Jr..

Where to Watch Grey’s Anatomy – Season 5

Grey’s Anatomy – Season 5 is currently listed on Amazon Video, Fandango At Home, and Hulu. Availability may vary by region and subscription tier.

How Grey’s Anatomy – Season 5 Fits the Series

This season entry highlights arc-specific developments and how Grey’s Anatomy – Season 5 connects to the series timeline.

Is Grey’s Anatomy – Season 5 Safe to Watch? (Age Rating Guide)

Official age rating not available.

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For verified credits, release details, or official resources, visit IMDb and Official Site.

Director	Not available
Main Cast	Ellen Pompeo, Chandra Wilson, Sandra Oh, Justin Chambers, James Pickens Jr.
Release Year	2008
Genre	Not available

Frequently Asked Questions

When was Grey’s Anatomy – Season 5 released?

Grey’s Anatomy – Season 5 was released on September 25, 2008.

What is Grey’s Anatomy – Season 5 about?

Live for the moment. Dive deeper into the lives and loves of "Grey's Anatomy"! The doctors struggle and thrive as they enter uncharted territories of life.

Where can I watch Grey’s Anatomy – Season 5?

Grey’s Anatomy – Season 5 is available on Amazon Video, Fandango At Home, and Hulu.

Dream a Little Dream of Me (1)

Episode 1 September 25, 2008 43m

Dream a Little Dream of Me (1)

As Meredith and Derek begin to find that their "happily ever after" is anything but easy, Cristina develops a crush on a military doctor who brings in a trauma patient. Meanwhile, the Chief and his staff cope with the news that Seattle Grace is no longer considered a top-tier teaching hospital.

Dream a Little Dream of Me (2)

Episode 2 September 25, 2008 43m

Dream a Little Dream of Me (2)

Alex is offended when Izzie talks about how great a man Alex is to Meredith. Derek is stabbed with the scalpel in the palm of his hand by Rose, while the Chief is stunned over Mercy West's increase in the number of patients, a deadly ice storm ravages Seattle.

Here Comes the Flood

Episode 3 October 9, 2008 43m

Here Comes the Flood

When the plumbing springs a leak, chaos breaks out at Seattle Grace as the Chief tries to put in place new teaching methods. Meanwhile, George takes his residency exam; and Derek attempts to get Meredith's roommates to move out, much to their surprise.

Brave New World

Episode 4 October 16, 2008 43m

Brave New World

Meredith is sent into a state of panic when Derek finds her mother's diary in the house. Meanwhile, Callie stresses while preparing for her first date with Erica. Later, Cristina stumbles across a part of the hospital no one has ever seen before.

There's No 'I' in Team

Episode 5 October 23, 2008 43m

There's No 'I' in Team

Bailey heads up a "domino procedure" in which each surgery hinges on the one preceding it. Meanwhile, Derek gets sole credit for the brain-tumor study he did with Meredith; Lexie tries to get George to notice her romantically; and Sloan counsels a desperate Callie in the ways of love.

Life During Wartime

Episode 6 October 30, 2008 43m

Life During Wartime

The chief gives Bailey new power and responsibility. He also gives her a very difficult surgical assignment: remove a girl's inoperable tumor. Meanwhile, new trauma chief Owen (Kevin McKidd) challenges the attendings' methods and the residents' skills.

Rise Up

Episode 7 November 6, 2008 43m

Rise Up

When the Chief makes an announcement that a solo surgery is up as an award, the residents are sent into a frenzy all trying to get an edge over one another. Meanwhile, Derek asks Bailey for advice after Cristina continues to interfere in his relationship with Meredith. Elsewhere, Erica uncovers a shocking connection between a resident and a patient.

These Ties That Bind

Episode 8 November 13, 2008 43m

These Ties That Bind

One of Meredith's oldest friends, Sadie, becomes an intern at Seattle Grace, but Mer's friends are less-than-welcoming to her.

In the Midnight Hour

Episode 9 November 20, 2008 43m

In the Midnight Hour

Meredith, Cristina and Bailey come to Lexie and Sadie's rescue when a routine surgery goes horribly wrong, as Owen and Derek treat a man seriously injured while sleepwalking and Mark comforts the sleepwalker's distraught daughter.

All by Myself

Episode 10 December 4, 2008 43m

All by Myself

Cristina is awarded the first solo surgery among the residents, but she is forced to give it up and choose her replacement; Lexie is impressed when Mark performs a cutting-edge procedure; Callie doesn't know if Sadie is friendly or flirtatious.

Wish You Were Here

Episode 11 January 8, 2009 43m

Wish You Were Here

Bailey teams with Seattle Grace's new pediatric surgeon, Dr. Arizona Robbins, to save the life of a young patient near and dear to her heart, as the admittance of a death row inmate at the hospital stirs anger in Derek and further erodes Meredith and Cristina's friendship; meanwhile, Callie and Sloan work as a team to fight their respective attractions to Sadie and Lexie, and Izzie tells Alex that she's seeing Denny.

Sympathy for the Devil

Episode 12 January 15, 2009 43m

Sympathy for the Devil

Derek's mother, Carolyn, makes a surprise visit to Seattle and meets Meredith for the first time, as Mark tries to conceal his relationship with Lexie from her as well; meanwhile, death row inmate William wishes to donate his organs to Bailey and Arizona's patient, as Owen and Cristina try to go on their first date.

Stairway to Heaven

Episode 13 January 22, 2009 43m

Stairway to Heaven

Bailey grows desperate as a patient's condition becomes more and more dire. Everyone in the hospital is stepping up to try to find the boy a new organ donor, including Meredith, who considers a death row patient's wish to die before execution. Meanwhile, an injury leaves Mark in a compromising position in the OR and Cristina awkwardly avoids Owen.

Beat Your Heart Out

Episode 14 February 5, 2009 43m

Beat Your Heart Out

Now that Derek has the engagement ring, he searches for the perfect way to propose to Meredith, as Lexie demands that Mark go public with their relationship, and Bailey, encouraged by her work on recent cases and by Dr. Dixon, considers a new direction for her medical career.

Before and After

Episode 15 February 12, 2009 43m

Before and After

Addison, Naomi and Sam rush the ailing Archer to Seattle Grace and reunite with old friends Derek and Mark to help save his life; meanwhile, Izzie employs her fellow doctors in a medical game designed to help teach the interns, and Owen runs into a significant someone from his past

An Honest Mistake

Episode 16 February 19, 2009 43m

An Honest Mistake

Derek's confidence is shaken like never before as he faces off with Addison over what course is best for their dying pregnant patient; Cristina calls the abilities of a renown surgeon into question after she botches a standard procedure; and Bailey, who has decided to pursue a fellowship in Pediatrics, is appalled by the Chief's less-than-stellar recommendation letter.

I Will Follow You Into the Dark

Episode 17 March 12, 2009 43m

I Will Follow You Into the Dark

Derek decides to quit after learning that more of his patients have died than survived; Izzie's interns make an unsettling discovery about "Patient X."

Stand By Me

Episode 18 March 19, 2009 43m

Stand By Me

After his fellow surgeons try and fail to bring Derek back to work, Meredith must summon the strength to convince him. Meanwhile the hospital is abuzz as Mark attempts a rare face transplant surgery. Cristina, at last awarded her first solo surgery, is more focused on the needs of her friends, and Izzie does her best to keep her medical condition a secret.

Elevator Love Letter

Episode 19 March 26, 2009 43m

Elevator Love Letter

All eyes are on Derek as he is set to perform his first surgery after his breakdown; attention is also set on Izzie, whose medical condition requires her to undergo a difficult surgery; and Owen has another PTSD episode that injures Cristina and traumatizes both of them, throwing the future of their relationship into question.

Sweet Surrender

Episode 20 April 23, 2009 43m

Sweet Surrender

As she endures aggressive treatment for her cancer, Izzie throws herself into planning Derek and Meredith's wedding.

No Good at Saying Sorry (One More Chance)

Episode 21 April 30, 2009 43m

No Good at Saying Sorry (One More Chance)

As preparations continue for Meredith and Derek's wedding, Izzie receives a surprise hospital visit from her handful-of-a-mother, Robbie. Meanwhile, a newly sober Thatcher visits his daughters, Meredith and Lexie, in order to make amends, and the Chief and Meredith bitterly fight over a controversial medical case.

What a Difference a Day Makes

Episode 22 May 7, 2009 43m

What a Difference a Day Makes

As Meredith, Derek and all of their friends prepare for the big wedding, a group of college students, injured in a car crash as they were heading to their graduation ceremony, is admitted to the ER. Meanwhile, Izzie fears the worst when she begins experiencing familiar symptoms.

Here's to Future Days

Episode 23 May 14, 2009 43m

Here's to Future Days

In the first part of the two hour season finale, Izzie spends time with a fellow cancer patient and contemplates whether or not to undergo a risky surgery, as Mark is ready to take his relationship with Lexie to the next level and a patient makes Owen reassess his place at Seattle Grace.

Now or Never

Episode 24 May 14, 2009 43m

Now or Never

In the second part of the two hour season finale, George delivers stunning news to Bailey, sending shockwaves throughout the hospital, and Izzie's friends anxiously await her recovery from surgery. Meanwhile Bailey is surprisingly displeased after being accepted into the pediatric fellowship program, and the victim of a near-fatal traffic accident brings the talents of Seattle Grace's doctors together. This is the second hour of a 2-hour season finale.

Ellen Pompeo

Ellen Pompeo

Meredith Grey

Chandra Wilson

Chandra Wilson

Miranda Bailey

Sandra Oh

Sandra Oh

Cristina Yang

Justin Chambers

Justin Chambers

Alex Karev

James Pickens Jr.

James Pickens Jr.

Richard Webber

Patrick Dempsey

Patrick Dempsey

Derek Shepherd

Kevin McKidd

Kevin McKidd

Owen Hunt

Katherine Heigl

Katherine Heigl

Izzie Stevens

Sara Ramirez

Sara Ramirez

Callie Torres

Eric Dane

Eric Dane

Mark Sloan

Chyler Leigh

Chyler Leigh

Lexie Grey

T. R. Knight

T. R. Knight

George O'Malley